Physiologic principles underlying ion channelopathies

Genetic Testing for Cardiac Ion Channelopathies

Ion channelopathies: a tapped-out mine?

THE STUDY OF ION CHANNELS shifted paradigms when Keating and colleagues (3) struck silver in the Utah hills. In the early days of the molecular biological era, they were able to describe a genetic linkage between the long QT syndrome, a form of inherited sudden death associated with a particular electrocardiographic finding, and ion channel DNA mutations. They went on to describe a plausible me...

Basic principles underlying coagulation

This chapter will discuss coagulation in the context of a hemostatic response to a break in the vasculature. Coagulation is the process that leads to fibrin formation; this process involves controlled interactions between protein coagulation factors. Hemostasis is coagulation that occurs in a physiological (as opposed to pathological) setting and results in sealing a break in the vasculature. T...

Underlying principles of restoration

The term restoration is used in many ways; however, it normally implies return to an original state. In ecological restoration, it should be thought of as applying to whole ecosystems. It must be remembered that options, such as rehabilitation or replacement, exist that may be more practicable than restoration. The components of restoration are the chemical and physical aspects of the habitat a...

Investigating Underlying Principles to Guide Health Impact Assessment

Background Many countries conduct Health Impact Assessment (HIA) of their projects and policies to predict their positive and negative health impacts. In recent years many guides have been developed to inform HIA practice, largely reflecting local developments in HIA. These guides have often been designed for specific contexts and specific need, making the choice between guides difficult. The o...